Dr. Alexander Schacht

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As someone who found my way into statistics late—only halfway through university—I often wonder: what if more young people knew about this path earlier?

In this episode, I sit down with two wonderful guests and PSI volunteers, Emma Crawford and Alex Spiers, to explore exactly that: how we, as statisticians and scientists, can inspire the next generation.

We talk about the why behind investing in STEM outreach, share personal stories, and get into the practical steps you can take—whether you want to volunteer at a school, present virtually, or simply start a conversation with a student.

What You’ll Learn in This Episode:

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Why and how you can promote more students become statisticians

Dr. Alexander Schacht

All Episodes

As someone who found my way into statistics late—only halfway through university—I often wonder: what if more young people knew about this path earlier?

In this episode, I sit down with two wonderful guests and PSI volunteers, Emma Crawford and Alex Spiers, to explore exactly that: how we, as statisticians and scientists, can inspire the next generation.

We talk about the why behind investing in STEM outreach, share personal stories, and get into the practical steps you can take—whether you want to volunteer at a school, present virtually, or simply start a conversation with a student.

What You’ll Learn in This Episode:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

Group sequential trials, interim analyses, final analyses, updated analyses… what do these terms actually mean, and why is there so much confusion?

In this technical yet highly practical episode, I speak with Kaspar Rufibach, Principal Biostatistician at Roche, to unpack some of the most commonly misunderstood terminology and concepts in clinical trial design and analysis.

If you’ve ever questioned what really qualifies as an “interim analysis” or struggled to explain why a “final analysis” isn’t always the last word, this conversation is for you.

What You’ll Learn in This Episode:

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Clarifying confusions around interim, primary, final, and other analyses in clinical trial

Dr. Alexander Schacht

All Episodes

Group sequential trials, interim analyses, final analyses, updated analyses… what do these terms actually mean, and why is there so much confusion?

In this technical yet highly practical episode, I speak with Kaspar Rufibach, Principal Biostatistician at Roche, to unpack some of the most commonly misunderstood terminology and concepts in clinical trial design and analysis.

If you’ve ever questioned what really qualifies as an “interim analysis” or struggled to explain why a “final analysis” isn’t always the last word, this conversation is for you.

What You’ll Learn in This Episode:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I had the pleasure of speaking with Prof. Holger Fröhlich, who leads the AI and Data Science Group at the Fraunhofer Institute and is an honorary professor at the University of Bonn. We explored one of the hottest topics in healthcare data science right now: synthetic data.

Holger and I discussed how synthetic data is generated using AI, what role digital twins could play in the future of clinical trials, and how these innovations could fundamentally reshape how we design and conduct research. We dove into the Cynthia Project, which is part of the Innovative Health Initiative (IHI) – the largest public-private partnership for health research in Europe.

What You’ll Learn in This Episode:

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Reimagining Clinical Trials with Synthetic Data and Digital Twins

Dr. Alexander Schacht

All Episodes

In this episode, I had the pleasure of speaking with Prof. Holger Fröhlich, who leads the AI and Data Science Group at the Fraunhofer Institute and is an honorary professor at the University of Bonn. We explored one of the hottest topics in healthcare data science right now: synthetic data.

Holger and I discussed how synthetic data is generated using AI, what role digital twins could play in the future of clinical trials, and how these innovations could fundamentally reshape how we design and conduct research. We dove into the Cynthia Project, which is part of the Innovative Health Initiative (IHI) – the largest public-private partnership for health research in Europe.

What You’ll Learn in This Episode:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I’m diving into a topic that’s very personal to me—working in an English-speaking environment as a non-native speaker. If you’ve ever felt unsure about your English skills in meetings, emails, or presentations, you’re not alone. I’ve been there myself, and I want to share what’s helped me grow more confident and effective over the years.

I’ll walk you through practical strategies that go beyond grammar—things that have really made a difference for me in both speaking and writing, and most importantly, in getting my message across clearly.

🧠 What You’ll Learn:

Weiterlesen …

Working in an english work environment as a non-native speaker

Dr. Alexander Schacht

All Episodes

In this episode, I’m diving into a topic that’s very personal to me—working in an English-speaking environment as a non-native speaker. If you’ve ever felt unsure about your English skills in meetings, emails, or presentations, you’re not alone. I’ve been there myself, and I want to share what’s helped me grow more confident and effective over the years.

I’ll walk you through practical strategies that go beyond grammar—things that have really made a difference for me in both speaking and writing, and most importantly, in getting my message across clearly.

🧠 What You’ll Learn:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I’m once again joined by Daniel Sabanés Bové for a deep dive into one of the most impactful tools for statisticians working with data visualization—R-Shiny.

We explore how interactive data visualizations can help you iterate faster, collaborate better across functions, and focus more on the actual scientific questions rather than just coding. Daniel shares some excellent examples from clinical trials and gives practical tips on how to avoid common pitfalls when building Shiny apps.

Whether you’re designing your first app or maintaining a more complex one, you’ll find plenty of value in this conversation—from best practices around UI/UX design to strategies for modular development and testing.

What You’ll Learn in This Episode:

Weiterlesen …

R-shiny – how to set it up effectively and avoid common mistakes

Dr. Alexander Schacht

All Episodes

In this episode, I’m once again joined by Daniel Sabanés Bové for a deep dive into one of the most impactful tools for statisticians working with data visualization—R-Shiny.

We explore how interactive data visualizations can help you iterate faster, collaborate better across functions, and focus more on the actual scientific questions rather than just coding. Daniel shares some excellent examples from clinical trials and gives practical tips on how to avoid common pitfalls when building Shiny apps.

Whether you’re designing your first app or maintaining a more complex one, you’ll find plenty of value in this conversation—from best practices around UI/UX design to strategies for modular development and testing.

What You’ll Learn in This Episode:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I’m sharing three personal stories where soft skills—or better yet, human skills—made a huge difference in my work as a statistician.

Whether it was building trust to access critical data, presenting results in a way that truly resonated, or negotiating a fair contract, these experiences reminded me how essential these skills are alongside our technical expertise.

🧠 What You’ll Learn:

Weiterlesen …

3 personal stories of how soft skills have helped me as a statistician

Dr. Alexander Schacht

All Episodes

In this episode, I’m sharing three personal stories where soft skills—or better yet, human skills—made a huge difference in my work as a statistician.

Whether it was building trust to access critical data, presenting results in a way that truly resonated, or negotiating a fair contract, these experiences reminded me how essential these skills are alongside our technical expertise.

🧠 What You’ll Learn:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I’m joined once again by Daniel Sabanés Bové to talk all about R packages—why they’re so useful, when to create one, and how to do it effectively. Whether you’re just starting out with writing reusable functions or thinking about building a more robust and reusable R package, you’ll find plenty of hands-on advice in our discussion.

Daniel shares his experiences from working at Roche, Google, and now through his consultancy, Rconis. We dive into everything from writing clean and consistent code, to testing, documenting, and even promoting your package in the open-source world.

What You’ll Learn in This Episode

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R-packages – best practices and useful tools

Dr. Alexander Schacht

All Episodes

In this episode, I’m joined once again by Daniel Sabanés Bové to talk all about R packages—why they’re so useful, when to create one, and how to do it effectively. Whether you’re just starting out with writing reusable functions or thinking about building a more robust and reusable R package, you’ll find plenty of hands-on advice in our discussion.

Daniel shares his experiences from working at Roche, Google, and now through his consultancy, Rconis. We dive into everything from writing clean and consistent code, to testing, documenting, and even promoting your package in the open-source world.

What You’ll Learn in This Episode

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this Friday episode, I’m sharing some hard-earned lessons on delegating programming tasks—something that completely changed the way I work and lead.

I didn’t start out knowing how to delegate effectively. Like many of you, I just figured it out as I went. Over time, I reached a point where I didn’t even need a SAS license anymore because I had fully delegated all my programming tasks. But getting to that level of trust and clarity wasn’t always straightforward—especially with SOPs in the mix.

SOPs are meant to guide us, but I’ve found they can both support and limit effective delegation. In this episode, I break down what SOPs do well, where they fall short, and what really matters when assigning work to others.

🔍 I’ll walk you through:

Weiterlesen …

Delegating programming tasks – how SOPs help and hinder

Dr. Alexander Schacht

All Episodes

In this Friday episode, I’m sharing some hard-earned lessons on delegating programming tasks—something that completely changed the way I work and lead.

I didn’t start out knowing how to delegate effectively. Like many of you, I just figured it out as I went. Over time, I reached a point where I didn’t even need a SAS license anymore because I had fully delegated all my programming tasks. But getting to that level of trust and clarity wasn’t always straightforward—especially with SOPs in the mix.

SOPs are meant to guide us, but I’ve found they can both support and limit effective delegation. In this episode, I break down what SOPs do well, where they fall short, and what really matters when assigning work to others.

🔍 I’ll walk you through:

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode, I welcome back Necdet Gunsoy, who’s now in a new role as the founder of EviMed, a boutique consultancy specializing in health economics, outcomes research, real-world evidence, and market access.

We dive into the often tense relationship between statisticians and market access professionals, exploring why these functions struggle to collaborate and, more importantly, how we can work together more effectively.

What You’ll Learn in This Episode

Weiterlesen …

Statistics and Market access – from foes to friends

Dr. Alexander Schacht

All Episodes

In this episode, I welcome back Necdet Gunsoy, who’s now in a new role as the founder of EviMed, a boutique consultancy specializing in health economics, outcomes research, real-world evidence, and market access.

We dive into the often tense relationship between statisticians and market access professionals, exploring why these functions struggle to collaborate and, more importantly, how we can work together more effectively.

What You’ll Learn in This Episode

Weiterlesen …

Dr. Alexander Schacht

All Episodes

In this episode of The Effective Statistician podcast, I dive into the art of persuasion. As statisticians and data scientists, we often rely on logic and data, but true influence requires more than just being right.

Drawing from ancient Greek philosophy, I explore the three pillars of persuasion—ethos (credibility), logos (logic), and pathos (emotion)—and share practical strategies to help you effectively convince others.

Whether you are presenting new methodologies, influencing key stakeholders, or advocating for change, this episode will equip you with essential communication skills to make a lasting impact.

What You’ll Learn in This Episode

Weiterlesen …

Beyond logic – how to convince others of your ideas

Dr. Alexander Schacht

All Episodes

In this episode of The Effective Statistician podcast, I dive into the art of persuasion. As statisticians and data scientists, we often rely on logic and data, but true influence requires more than just being right.

Drawing from ancient Greek philosophy, I explore the three pillars of persuasion—ethos (credibility), logos (logic), and pathos (emotion)—and share practical strategies to help you effectively convince others.

Whether you are presenting new methodologies, influencing key stakeholders, or advocating for change, this episode will equip you with essential communication skills to make a lasting impact.

What You’ll Learn in This Episode

Weiterlesen …