Reine Escalona

What is Strategy

In the ever-evolving landscape of professional development, I’ve noticed that the term “strategy” is frequently thrown around, often without a clear understanding of its true meaning. Unfortunately, this misunderstanding often leads to the formulation of ineffective strategies, a topic explored by Richard Rumelt in his book Good Strategy/Bad Strategy. In that ancient conflict, Hannibal faced …

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Estimands in Observational Studies

Ever wondered about the intricate connections between observational studies and the Estimand framework in the pharmaceutical industry? How do the challenges in multi-country primary data collection unfold, and what crucial role do assumptions play in propensity score methods? In this captivating episode, I’m excited to have Artemis Koukounari, an accomplished statistician and associate director in …

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From Ethics Guidelines to Implementing Ethical Statistics

This time, I’m engaging in a conversation with Katharina, and I must say I’m thrilled to explore more on the topic of ethical statistics. In our previous discussion, we delved into the importance of ethical guidelines, particularly focusing on the ISI declaration of Ethics.  Today, we aim to take things a step further – moving …

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Defining Clinical Trial Estimands: A Practical Guide for Study Teams with Examples including Regulatory Buy-in

This is an extraordinary episode that takes us deep into the world of modern pharmaceutical research. Today, we are embarking on a captivating journey guided by the insightful dialogue between Elena Polverejan and me. Throughout this episode, we uncover the potential of the Estimands Framework.  Join us as we delve into the origins of Estimands, …

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Cross-Over Studies: When Do They Offer a Great Advantage?

I’m thrilled to dive into a topic that has been untouched in the past 300 episodes – crossover studies. It’s a classical design that offers unique advantages, yet it’s often overlooked. Joining me today is Markus Savli, a biostatistician with a diverse background in biomedical engineering, mathematics, and epidemiology. Together, we’ll explore the intricacies of …

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